Regulation of phosphatase activity

Across TCGA cell cohorts, RNA activity of the Regulation of phosphatase activity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1B2, PHB2, and SLC25A27, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatase activity activity versus EEF1B2 in OESOPHAGUS (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EEF1B2 →	-0.780	-0.267	.004	.009	3	6
OVARY	PHB2 →	-0.984	-1.336	.007	.001	3	5
SOFT_TISSUE	SLC25A27 →	+1.175	+1.420	.008	.001	2	5
SOFT_TISSUE	TMEM154 →	+1.978	+1.447	.005	.001	3	4
SOFT_TISSUE	TOP1MT →	-0.913	-1.719	.001	<.001	3	4
SOFT_TISSUE	NRP1 →	+3.624	+1.377	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010921 vs EEF1B2 — OESOPHAGUS

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