Regulation of inositol phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of inositol phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF6, CD40LG, and FCRLA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inositol phosphate biosynthetic process activity versus ARHGEF6 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGEF6 →	+0.358	+0.237	.001	.003	3	5
LUAD	CD40LG →	+0.606	+0.272	<.001	.006	3	4
PDAC	FCRLA →	+1.016	+0.620	<.001	<.001	3	4
PDAC	TESPA1 →	+0.619	+0.454	<.001	.001	2	5
PDAC	CD6 →	+0.522	+0.402	.004	.008	3	4
PDAC	CD28 →	+0.598	+0.435	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010919 vs ARHGEF6 — LUAD

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