Positive regulation of mitochondrial membrane potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial membrane potential pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCP, MS4A1, and ARG1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCP grouped by Positive regulation of mitochondrial membrane potential-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VCP →	-1.050	-0.853	<.001	.001	3	14
BREAST	MS4A1 →	+0.143	+0.223	<.001	<.001	3	4
BONE	ARG1 →	+0.137	+0.203	.001	.006	3	4
BONE	ZNF491 →	+0.159	+0.222	.001	.002	3	4
PANCREAS	PPARA →	+0.413	+0.226	<.001	.004	3	4
OESOPHAGUS	NLRP12 →	+0.142	+0.225	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCP by Positive regulation of mitochondrial membrane potential activity — LARGE_INTESTINE

Explore this box plot interactively →