Regulation of very-low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H4, LGALS1, and MCHR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of very-low-density lipoprotein particle clearance activity versus GTF2H4 in HNSC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GTF2H4 →	-0.108	-0.048	.008	<.001	3	3
COAD	LGALS1 →	+0.640	+0.116	.001	.004	3	3
COAD	MCHR1 →	+0.247	+0.116	<.001	.003	3	3
COAD	TPM4 →	+0.407	+0.118	<.001	.002	3	3
OV	CFD →	+1.206	+0.078	<.001	<.001	3	3
UCEC	RFC5 →	-0.369	-0.096	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010915 vs GTF2H4 — HNSC

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