Regulation of very-low-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1E, P3H3, and TMEM238, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5F1E grouped by Regulation of very-low-density lipoprotein particle clearance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATP5F1E →	-0.980	-1.128	.001	<.001	3	4
PANCREAS	P3H3 →	-4.135	-2.131	<.001	<.001	3	4
PANCREAS	TMEM238 →	+0.980	+1.410	.005	.001	3	4
PANCREAS	CCDC28A →	-0.840	-1.516	.001	<.001	3	4
LUNG_SCLC	KIF14 →	+0.921	+1.820	.003	<.001	3	3
LUNG_SCLC	CCDC142 →	+0.900	+1.632	.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5F1E by Regulation of very-low-density lipoprotein particle clearance activity — SKIN

Explore this box plot interactively →