Regulation of very-low-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle clearance pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Panobinostat, Etoposide, and DMOG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Panobinostat grouped by Regulation of very-low-density lipoprotein particle clearance-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Panobinostat →	+0.450	+1.881	.025	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	Etoposide →	+1.483	+0.591	.045	.018	3	2
BONE	DMOG →	+0.634	+0.644	.025	.008	3	2
BONE	GSK2830371A →	+0.696	+0.445	.006	.038	3	2
BONE	LMB_AB2 →	+0.630	+0.445	<.001	.038	3	2
BONE	Venetoclax →	+0.509	+0.445	.008	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Panobinostat by Regulation of very-low-density lipoprotein particle clearance activity — BLOOD_Leukemia

Explore this box plot interactively →