Regulation of very-low-density lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP9_S475, GGA3, and SHMT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of very-low-density lipoprotein particle remodeling activity versus ARHGAP9_S475 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP9_S475 →	+0.563	+0.346	<.001	.001	3	6
LSCC	GGA3 →	+0.188	+0.123	.001	<.001	3	5
PDAC	SHMT1 →	+0.279	+0.685	.001	.003	3	4
PDAC	LECT2 →	-0.519	-0.531	<.001	.001	3	4
GBM	CARD9 →	+0.413	+0.428	<.001	<.001	3	4
GBM	AMPD3_S85 →	+0.408	+0.310	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010901 vs ARHGAP9_S475 — GBM

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