Regulation of very-low-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM4, DYNC2LI1, and IFI27L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM4 grouped by Regulation of very-low-density lipoprotein particle remodeling-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MDM4 →	+0.842	+1.941	.004	<.001	3	6
LUNG_SCLC	DYNC2LI1 →	+0.904	+1.246	.001	.001	3	5
KIDNEY	IFI27L1 →	-1.195	-1.279	<.001	.001	3	5
BREAST	AMPD3 →	-0.552	-1.041	.003	<.001	3	5
BREAST	POLR3K →	+1.061	+0.994	<.001	.003	3	5
BREAST	LAMB3 →	-2.300	-0.767	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM4 by Regulation of very-low-density lipoprotein particle remodeling activity — BLOOD_Myeloma

Explore this box plot interactively →