Regulation of very-low-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A20, PSMC3IP, and EIF5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A20 grouped by Regulation of very-low-density lipoprotein particle remodeling-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC25A20 →	-0.190	-0.833	.005	.004	3	4
OVARY	PSMC3IP →	-0.358	-1.717	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	EIF5B →	-0.233	-2.166	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TTC34 →	-0.212	-2.383	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	NFYC →	-0.262	-2.129	.003	.002	3	3
SOFT_TISSUE	POLR2I →	-0.321	-1.454	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A20 by Regulation of very-low-density lipoprotein particle remodeling activity — BREAST

Explore this box plot interactively →