Regulation of very-low-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPK1, NFAT5, and TLE6, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITPK1 grouped by Regulation of very-low-density lipoprotein particle remodeling-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITPK1 →	+0.135	+1.767	.006	.005	1	1
LIVER	NFAT5 →	+0.185	+1.767	.003	.005	1	1
LIVER	TLE6 →	+0.205	+1.767	.009	.005	1	1
LIVER	SERPINE1 →	-0.335	-1.767	.008	.005	1	1
LIVER	CRTAM →	+0.084	+1.767	.003	.005	1	1
LIVER	NCL →	-0.275	-1.767	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITPK1 by Regulation of very-low-density lipoprotein particle remodeling activity — LIVER

Explore this box plot interactively →