Positive regulation of triglyceride catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AADAC, TOP2A_S1247, and UTP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride catabolic process activity versus AADAC in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AADAC →	+0.939	+0.072	<.001	<.001	3	4
BRCA	TOP2A_S1247 →	-0.718	-0.057	.002	.001	3	4
BRCA	UTP4 →	-0.376	-0.053	.003	.009	3	4
LUAD	WDR75_S779 →	-0.432	-0.076	<.001	.002	3	4
PDAC	CBX2 →	-1.006	-0.088	.004	.006	3	4
LUAD	TP53BP1_S316 →	-0.664	-0.071	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010898 vs AADAC — LSCC

Explore this scatter interactively →