Positive regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFE4, APOC2, and STRAP, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride catabolic process activity versus NFE4 in BLOOD_Leukemia (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NFE4 →	+5.600	+2.115	.006	.003	2	1
BLOOD_Leukemia	APOC2 →	+7.755	+1.847	.001	.003	2	1
BLOOD_Leukemia	STRAP →	-0.754	-2.020	.005	.008	2	1
BLOOD_Leukemia	TNFSF12 →	+1.700	+2.115	<.001	.003	2	1
BLOOD_Leukemia	JMJD7 →	+0.489	+1.847	.005	.003	2	1
BLOOD_Leukemia	AP5B1 →	+1.299	+2.115	.009	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010898 vs NFE4 — BLOOD_Leukemia

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