Positive regulation of sequestering of triglyceride

Across TCGA patient cohorts, RNA activity of the Positive regulation of sequestering of triglyceride pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA8K, METTL14, and TTC33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sequestering of triglyceride activity versus GOLGA8K in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GOLGA8K →	+0.144	+0.699	.002	.002	3	4
OV	METTL14 →	-0.464	-0.629	.003	.005	3	3
CCRCC	TTC33 →	-0.257	-0.681	.003	<.001	3	3
CCRCC	CNTNAP5 →	-1.193	-0.559	.002	.008	3	3
CCRCC	KCTD16 →	-1.243	-0.773	<.001	<.001	3	3
CCRCC	HDHD5-AS1 →	-0.462	-0.577	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010890 vs GOLGA8K — CCRCC

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