Regulation of sequestering of triglyceride

Across TCGA patient cohorts, RNA activity of the Regulation of sequestering of triglyceride pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, DAB2, and RRP36_S73, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sequestering of triglyceride activity versus TLN2 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.534	+0.055	<.001	.002	3	7
BRCA	DAB2 →	+0.390	+0.064	<.001	<.001	3	7
PDAC	RRP36_S73 →	-0.474	-0.055	.002	<.001	3	6
BRCA	SORBS1 →	+0.488	+0.046	.001	<.001	3	6
PDAC	SORBS3 →	+0.345	+0.056	<.001	<.001	3	6
OV	ALDH2 →	+0.727	+0.045	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010889 vs TLN2 — BRCA

Explore this scatter interactively →