Regulation of sequestering of triglyceride

Across TCGA cell cohorts, RNA activity of the Regulation of sequestering of triglyceride pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCF2L, ALOX12B, and CDC27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCF2L grouped by Regulation of sequestering of triglyceride-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MCF2L →	+2.967	+1.169	.009	.006	3	4
KIDNEY	ALOX12B →	+0.677	+1.721	<.001	<.001	3	4
LIVER	CDC27 →	-0.873	-1.702	.009	.008	3	3
BLOOD_Lymphoma	LARS2 →	+0.696	+2.011	.004	<.001	3	3
BLOOD_Lymphoma	TEX52 →	+1.003	+2.011	.007	<.001	3	3
BREAST	METTL8 →	+0.520	+0.733	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCF2L by Regulation of sequestering of triglyceride activity — SKIN

Explore this box plot interactively →