Negative regulation of cholesterol storage

Across TCGA patient cohorts, RNA activity of the Negative regulation of cholesterol storage pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, CES1, and HNMT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol storage activity versus TNS2_S102 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2_S102 →	+0.569	+0.043	<.001	<.001	3	8
LSCC	CES1 →	+0.861	+0.072	<.001	<.001	3	8
GBM	HNMT →	+0.535	+0.079	<.001	<.001	3	7
CCRCC	KANK2_S540 →	+0.462	+0.055	<.001	.001	3	7
BRCA	HAAO →	+0.535	+0.064	.001	<.001	3	7
COAD	CRYL1 →	+0.453	+0.064	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010887 vs TNS2_S102 — BRCA

Explore this scatter interactively →