Regulation of cholesterol storage

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol storage pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, TNS2_S120, and CYGB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol storage activity versus TNS2_S102 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS2_S102 →	+1.061	+0.056	<.001	<.001	3	8
LSCC	TNS2_S120 →	+0.761	+0.109	<.001	<.001	3	8
OV	CYGB →	+0.723	+0.066	<.001	<.001	3	8
GBM	DAB2 →	+0.609	+0.065	<.001	<.001	3	8
OV	RENBP →	+0.459	+0.060	<.001	<.001	3	7
COAD	RPL10A →	-0.249	-0.085	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010885 vs TNS2_S102 — OV

Explore this scatter interactively →