Regulation of cholesterol storage

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol storage pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC1, CD180, and HMOX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol storage activity versus SIGLEC1 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIGLEC1 →	+1.045	+0.209	<.001	<.001	3	6
GBM	CD180 →	+0.868	+0.279	<.001	<.001	3	6
OV	HMOX1 →	+1.103	+0.261	<.001	<.001	3	5
OV	HCK →	+0.832	+0.161	.001	.001	3	5
OV	WIPF1 →	+0.806	+0.246	<.001	<.001	3	5
GBM	SIGLEC9 →	+1.257	+0.255	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010885 vs SIGLEC1 — OV

Explore this scatter interactively →