Regulation of cholesterol storage

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol storage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMA1, CD151, and CSTB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMA1 grouped by Regulation of cholesterol storage-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CMA1 →	-0.054	-1.350	.004	<.001	3	4
KIDNEY	CD151 →	-0.738	-1.063	.007	.009	3	4
LUNG_NSCLC_LUSC	CSTB →	+1.192	+1.421	.007	.002	3	3
BREAST	MAPKAPK5 →	-0.387	-0.706	.002	.002	3	3
LIVER	VPS37B →	-1.205	-0.619	.003	<.001	3	3
BREAST	CNTNAP3 →	+1.265	+0.824	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMA1 by Regulation of cholesterol storage activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →