Regulation of cholesterol storage

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol storage pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZKSCAN2, EAPP, and TYRO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol storage activity versus ZKSCAN2 in OESOPHAGUS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZKSCAN2 →	-0.588	-1.337	.001	.004	3	4
OESOPHAGUS	EAPP →	-0.837	-1.167	.008	.002	3	4
PANCREAS	TYRO3 →	+1.421	+1.741	<.001	<.001	3	4
STOMACH	BRMS1L →	-0.929	-1.175	.002	.001	3	4
STOMACH	TMEM243 →	+1.213	+1.328	.005	.004	2	5
STOMACH	WDR62 →	-1.297	-1.188	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010885 vs ZKSCAN2 — OESOPHAGUS

Explore this scatter interactively →