Positive regulation of lipid storage

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBKE, ZC3H12A, and C3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid storage activity versus IKBKE in BLOOD_Myeloma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IKBKE →	+1.711	+0.135	<.001	.002	3	14
OESOPHAGUS	ZC3H12A →	+1.714	+0.178	<.001	<.001	3	14
LIVER	C3 →	+4.733	+0.162	<.001	.007	3	12
LUNG_NSCLC_LUSC	TNIP1 →	+1.243	+0.114	<.001	.001	3	11
KIDNEY	CSF2 →	+2.683	+0.165	.003	<.001	3	10
LUNG_NSCLC_LUSC	CXCL2 →	+2.187	+0.136	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010884 vs IKBKE — BLOOD_Myeloma

Explore this scatter interactively →