Positive regulation of lipid storage

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCKDK, DARS1, and CD68, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid storage activity versus BCKDK in CNS (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BCKDK →	+0.419	+0.696	.005	.006	3	5
OESOPHAGUS	DARS1 →	+0.706	+1.193	<.001	.002	3	4
OVARY	CD68 →	+2.409	+1.265	<.001	<.001	3	4
LUNG_SCLC	RPS27L →	+0.851	+1.164	.003	<.001	3	4
URINARY_TRACT	WWTR1 →	+1.879	+1.967	.008	<.001	3	4
OVARY	TIMP1 →	+2.525	+1.063	.008	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010884 vs BCKDK — CNS

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