Regulation of lipid storage

Across TCGA patient cohorts, RNA activity of the Regulation of lipid storage pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, CYGB, and TNS2_S102, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid storage activity versus TNS2_S120 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNS2_S120 →	+0.533	+0.047	<.001	<.001	3	9
BRCA	CYGB →	+0.686	+0.055	<.001	<.001	3	8
OV	TNS2_S102 →	+0.970	+0.043	<.001	.002	3	8
BRCA	PDS5A →	-0.299	-0.039	.001	.001	3	8
COAD	PRKG1 →	+0.398	+0.028	<.001	<.001	3	8
BRCA	RSU1 →	+0.379	+0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010883 vs TNS2_S120 — LSCC

Explore this scatter interactively →