Regulation of lipid storage

Across TCGA patient cohorts, RNA activity of the Regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BP4, HNRNPA1, and CTDSPL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid storage activity versus SH3BP4 in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BP4 →	-0.744	-0.230	<.001	<.001	3	5
GBM	HNRNPA1 →	-0.372	-0.218	.004	<.001	3	4
GBM	CTDSPL2 →	-0.305	-0.165	<.001	<.001	3	4
HNSC	USP3 →	-0.399	-0.245	<.001	.001	3	4
GBM	NKRF →	-0.270	-0.214	.004	<.001	3	4
GBM	ZNF627 →	-0.409	-0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010883 vs SH3BP4 — HNSC

Explore this scatter interactively →