Regulation of lipid storage

Across TCGA cell cohorts, RNA activity of the Regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXND1, KRBA1, and PPA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLXND1 grouped by Regulation of lipid storage-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLXND1 →	+2.610	+0.332	.003	<.001	3	4
STOMACH	KRBA1 →	+1.888	+1.228	.008	.005	3	4
UPPER_AERODIGESTIVE_TRACT	PPA2 →	-0.696	-1.190	.009	.005	2	4
BONE	PLEKHG4B →	+1.676	+1.163	.003	.008	3	3
BLOOD_Lymphoma	PKD2 →	+2.306	+1.772	.006	<.001	3	3
BREAST	LRRC3 →	+0.639	+0.623	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLXND1 by Regulation of lipid storage activity — SOFT_TISSUE

Explore this box plot interactively →