Regulation of lipid storage

Across TCGA cell cohorts, RNA activity of the Regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, CDC25A, and SERPINH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid storage activity versus TIMELESS in KIDNEY (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TIMELESS →	-0.811	-0.232	.006	.006	3	4
KIDNEY	CDC25A →	-1.311	-0.318	.007	.001	3	4
BONE	SERPINH1 →	+2.874	+1.612	<.001	.006	3	3
STOMACH	PLIN3 →	+1.538	+1.160	<.001	.007	3	3
BLOOD_Lymphoma	SLC2A8 →	+1.219	+0.365	.004	.007	3	3
OESOPHAGUS	RBM14 →	-0.997	-1.182	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010883 vs TIMELESS — KIDNEY

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