Regulation of cardiac muscle contraction by calcium ion signaling

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle contraction by calcium ion signaling pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL2, ANK2, and ITSN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction by calcium ion signaling activity versus DPYSL2 in HNSC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DPYSL2 →	+0.320	+0.069	<.001	.007	3	7
HNSC	ANK2 →	+0.726	+0.103	<.001	<.001	3	7
PDAC	ITSN1 →	+0.321	+0.034	<.001	.002	3	7
HNSC	SVIL_S263 →	+0.916	+0.129	<.001	<.001	3	6
HNSC	CAMK2D →	+0.343	+0.066	<.001	<.001	3	6
UCEC	CLIC2 →	+0.584	+0.078	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010882 vs DPYSL2 — HNSC

Explore this scatter interactively →