Regulation of cardiac muscle contraction by calcium ion signaling

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle contraction by calcium ion signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPH, ADAM15, and ZCWPW1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction by calcium ion signaling activity versus ASPH in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ASPH →	+1.277	+0.163	.004	.003	3	5
BLOOD_Myeloma	ADAM15 →	+1.852	+0.316	<.001	<.001	3	4
LIVER	ZCWPW1 →	-0.487	-0.232	.005	.004	3	4
SKIN	TRIM38 →	+0.770	+0.214	.001	<.001	3	4
SKIN	MTMR6 →	+0.947	+0.214	.001	.005	3	4
KIDNEY	IRAK1 →	+1.233	+0.281	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010882 vs ASPH — LUNG_NSCLC_LUAD

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