Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUMBL, HSPB6, and TOP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum activity versus NUMBL in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUMBL →	+0.391	+0.065	<.001	.001	3	7
HNSC	HSPB6 →	+0.777	+0.098	<.001	<.001	3	7
LUAD	TOP1 →	-0.296	-0.036	.005	.002	3	6
HNSC	MAPRE2 →	+0.357	+0.111	<.001	<.001	3	6
UCEC	RSU1 →	+0.408	+0.061	<.001	<.001	3	6
BRCA	TMOD2 →	+0.428	+0.027	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010880 vs NUMBL — UCEC

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