Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNRD1, CBFB, and LKAAEAR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum activity versus TXNRD1 in SKIN (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TXNRD1 →	+0.790	+0.284	.004	<.001	3	4
SKIN	CBFB →	+0.653	+0.198	.003	.006	3	4
OESOPHAGUS	LKAAEAR1 →	-0.421	-0.398	.001	.006	3	3
BLOOD_Myeloma	OXCT1 →	+1.139	+0.224	<.001	<.001	3	3
OVARY	NEIL3 →	+1.047	+0.708	<.001	.001	3	3
OVARY	ATP8B3 →	+1.773	+0.635	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010880 vs TXNRD1 — SKIN

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