Regulation of cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMC4, STK17A, and THTPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMC4 grouped by Regulation of cholesterol efflux-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CMC4 →	-1.046	-1.246	<.001	<.001	3	5
PANCREAS	STK17A →	-0.916	-0.784	.005	.004	2	6
SOFT_TISSUE	THTPA →	-0.811	-1.484	<.001	<.001	3	4
CNS	TK2 →	-0.749	-0.763	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CGRRF1 →	-1.021	-0.845	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SNW1 →	-0.792	-0.791	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMC4 by Regulation of cholesterol efflux activity — BLOOD_Leukemia

Explore this box plot interactively →