Positive regulation of triglyceride biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TXNDC9_S188, IDH1, and UIMC1_S653, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride biosynthetic process activity versus TXNDC9_S188 in BRCA (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TXNDC9_S188 →	-0.524	-0.037	<.001	<.001	3	4
PDAC	IDH1 →	+0.192	+0.046	.006	.001	3	4
LUAD	UIMC1_S653 →	-0.272	-0.041	<.001	<.001	3	4
GBM	AHNAK_S2138 →	+0.372	+0.041	.008	.009	3	4
OV	GGA2 →	+0.291	+0.039	<.001	.001	3	4
PDAC	SYNPO_S501 →	+0.348	+0.027	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010867 vs TXNDC9_S188 — BRCA

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