Regulation of triglyceride biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFNG, P2RX1, and CHMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride biosynthetic process activity versus MFNG in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFNG →	+0.536	+0.726	<.001	<.001	3	4
PDAC	P2RX1 →	+0.742	+0.612	.001	<.001	3	4
LSCC	CHMP3 →	-0.313	-0.750	.002	<.001	3	4
BRCA	SDC1 →	-1.135	-0.528	<.001	.008	3	4
LSCC	BFSP1 →	-0.704	-0.611	<.001	.004	3	4
LSCC	SELENOI →	-0.582	-0.633	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010866 vs MFNG — LSCC

Explore this scatter interactively →