Regulation of triglyceride biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIX, FHOD3, and ZNF333, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFIX grouped by Regulation of triglyceride biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NFIX →	-2.126	-1.285	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	FHOD3 →	-1.719	-1.410	.007	.001	3	4
OVARY	ZNF333 →	-0.743	-0.854	.001	.001	3	4
SOFT_TISSUE	DNMT3A →	+1.511	+0.235	.003	.004	3	3
CNS	PI4K2A →	-0.482	-0.712	.001	.008	3	3
CNS	HSPA5 →	-0.709	-0.951	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFIX by Regulation of triglyceride biosynthetic process activity — OVARY

Explore this box plot interactively →