Regulation of triglyceride biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GKAP1, IFT122, and FAM229A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride biosynthetic process activity versus GKAP1 in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GKAP1 →	-0.675	-0.408	.002	.008	3	4
URINARY_TRACT	IFT122 →	-1.036	-0.281	.001	.003	3	4
URINARY_TRACT	FAM229A →	-1.623	-0.280	<.001	.003	3	4
KIDNEY	HIVEP3 →	+1.927	+0.335	<.001	.005	3	3
SOFT_TISSUE	CARF →	-0.813	-0.343	.007	.003	3	3
LUNG_NSCLC_LUSC	FBXO7 →	-0.979	-0.307	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010866 vs GKAP1 — LUNG_NSCLC_LUAD

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