Retina layer formation

Across TCGA patient cohorts, RNA activity of the Retina layer formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF565, GYG2P1, and KIAA0319, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina layer formation activity versus ZNF565 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF565 →	+0.302	+0.427	<.001	.009	3	3
GBM	GYG2P1 →	+0.162	+0.235	<.001	.002	3	3
GBM	KIAA0319 →	+0.912	+0.342	<.001	.001	3	3
PDAC	ITIH4 →	+0.129	+0.321	.006	.001	3	3
HNSC	SDK1 →	+0.988	+0.379	<.001	.003	3	3
UCEC	MBNL3 →	-0.532	-0.267	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010842 vs ZNF565 — BRCA

Explore this scatter interactively →