Retina layer formation

Across TCGA cell cohorts, RNA activity of the Retina layer formation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COA1, CCDC74A, and RNF41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina layer formation activity versus COA1 in SKIN (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COA1 →	-0.838	-1.507	.005	.004	3	5
STOMACH	CCDC74A →	-2.606	-1.615	.002	<.001	3	4
LUNG_NSCLC_LUAD	RNF41 →	-0.932	-1.544	.001	.001	3	4
STOMACH	MFSD8 →	+0.883	+1.615	.001	<.001	3	3
OVARY	TNKS →	-1.183	-1.571	.006	.005	3	3
OESOPHAGUS	WDR37 →	+0.952	+1.606	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010842 vs COA1 — SKIN

Explore this scatter interactively →