Telomere maintenance via telomere lengthening

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, PSRC1, and CNTROB, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via telomere lengthening activity versus PIF1 in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIF1 →	+1.611	+0.128	<.001	<.001	3	19
BLOOD_Leukemia	PSRC1 →	+1.358	+0.068	<.001	<.001	3	16
URINARY_TRACT	CNTROB →	+1.106	+0.109	<.001	.001	2	17
LUNG_NSCLC_LUSC	AURKB →	+1.361	+0.085	.002	.005	2	17
BLOOD_Lymphoma	NEURL4 →	+1.148	+0.064	<.001	<.001	3	16
BREAST	WRAP53 →	+1.225	+0.099	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010833 vs PIF1 — URINARY_TRACT

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