Negative regulation of glucose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of glucose transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8L2, BTK, and HCK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glucose transmembrane transport activity versus TNFAIP8L2 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFAIP8L2 →	+0.394	+0.064	<.001	<.001	3	8
LSCC	BTK →	+0.437	+0.051	<.001	<.001	3	8
GBM	HCK →	+0.601	+0.054	.001	.002	3	8
GBM	ARHGAP45 →	+0.465	+0.057	.003	.002	3	8
HNSC	RCSD1 →	+0.565	+0.073	<.001	.001	3	7
GBM	WAS →	+0.513	+0.065	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010829 vs TNFAIP8L2 — LSCC

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