Negative regulation of glucose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP6, LUC7L2, and ZKSCAN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glucose transmembrane transport activity versus RBBP6 in COAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBBP6 →	-0.333	-0.211	.003	.002	3	3
COAD	LUC7L2 →	-0.310	-0.187	<.001	.001	3	3
COAD	ZKSCAN2 →	-0.278	-0.205	.001	.001	3	3
LSCC	PHC3 →	-0.636	-0.187	<.001	.001	3	3
COAD	CKAP5 →	-0.455	-0.190	<.001	.001	3	3
COAD	IZUMO1 →	-0.207	-0.176	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010829 vs RBBP6 — COAD

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