Negative regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of glucose transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POMGNT1, H2BC13, and H2AC15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POMGNT1 grouped by Negative regulation of glucose transmembrane transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	POMGNT1 →	+0.290	+2.362	.002	.005	3	3
BONE	H2BC13 →	+0.377	+1.887	.001	<.001	3	3
PANCREAS	H2AC15 →	-0.396	-1.502	<.001	.001	3	3
BONE	PRSS33 →	-0.443	-2.065	.004	<.001	3	3
LUNG_NSCLC_LUAD	SYDE2 →	-0.122	-1.179	.002	.009	3	3
OVARY	HCCS →	-0.302	-0.811	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POMGNT1 by Negative regulation of glucose transmembrane transport activity — BLOOD_Lymphoma

Explore this box plot interactively →