Negative regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, TACSTD2, and KRT8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glucose transmembrane transport activity versus SDC4 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SDC4 →	+1.409	+0.871	.001	<.001	3	7
PANCREAS	TACSTD2 →	+7.085	+1.227	<.001	.009	3	7
OVARY	KRT8 →	+2.910	+0.876	.007	.003	3	6
PANCREAS	MUC20 →	+3.664	+1.219	.001	.009	3	6
BONE	TMOD3 →	+1.095	+1.610	.002	.001	2	7
LUNG_NSCLC_LUAD	DUSP10 →	+1.590	+1.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010829 vs SDC4 — BREAST

Explore this scatter interactively →