Positive regulation of glucose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MKLN1, TMF1, and MATR3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose transmembrane transport activity versus MKLN1 in UVM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MKLN1 →	+0.860	+0.036	<.001	<.001	3	32
UVM	TMF1 →	+1.410	+0.042	<.001	<.001	3	32
THYM	MATR3 →	+0.868	+0.045	<.001	<.001	3	32
UVM	DMXL1 →	+1.207	+0.037	<.001	<.001	3	32
THYM	NFAT5 →	+1.561	+0.050	<.001	<.001	3	31
UVM	PIKFYVE →	+1.172	+0.040	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010828 vs MKLN1 — UVM

Explore this scatter interactively →