Positive regulation of glucose transmembrane transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of glucose transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, ADD1, and NRDC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose transmembrane transport activity versus SORBS3 in PDAC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SORBS3 →	+0.346	+0.039	<.001	.003	3	8
GBM	ADD1 →	+0.443	+0.076	<.001	<.001	3	8
LSCC	NRDC →	-0.266	-0.060	<.001	<.001	3	8
BRCA	RPL5 →	-0.210	-0.038	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.812	+0.081	<.001	.002	3	8
OV	ESD →	+0.507	+0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010828 vs SORBS3 — PDAC

Explore this scatter interactively →