Positive regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC45A3, FST, and UBA52, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC45A3 grouped by Positive regulation of glucose transmembrane transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC45A3 →	+0.983	+0.602	<.001	.008	3	3
SKIN	FST →	+2.827	+0.481	<.001	.005	3	3
SKIN	UBA52 →	-0.437	-0.628	.001	.006	3	3
BLOOD_Leukemia	MBOAT7 →	+0.794	+0.421	.001	.006	3	3
LUNG_SCLC	RNF165 →	-1.763	-0.968	<.001	<.001	3	3
BLOOD_Leukemia	XK →	+2.605	+0.260	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC45A3 by Positive regulation of glucose transmembrane transport activity — CNS

Explore this box plot interactively →