Positive regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM120B, PLCD3, and NLRC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose transmembrane transport activity versus TMEM120B in LUNG_SCLC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM120B →	+0.554	+0.332	.002	<.001	2	5
LUNG_NSCLC_LUAD	PLCD3 →	-1.131	-0.365	<.001	<.001	3	4
LIVER	NLRC3 →	+0.101	+0.326	.003	.002	3	4
LUNG_NSCLC_LUSC	BCL2L13 →	-0.804	-0.539	.004	.001	3	4
SKIN	ZNF383 →	+0.738	+0.302	.005	.003	3	4
BLOOD_Leukemia	LAMTOR2 →	-0.802	-0.707	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010828 vs TMEM120B — LUNG_SCLC

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