Negative regulation of centrosome duplication

Across TCGA patient cohorts, RNA activity of the Negative regulation of centrosome duplication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, PLCL1, and CCDC34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of centrosome duplication activity versus AURKB in BRCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AURKB →	+0.747	+0.139	<.001	<.001	3	6
GBM	PLCL1 →	-0.754	-0.555	.001	.001	2	6
LSCC	CCDC34 →	+0.494	+0.482	<.001	<.001	3	5
OV	INCENP →	+0.719	+0.188	.001	.006	3	5
LSCC	LARP1 →	+0.517	+0.679	<.001	<.001	3	5
CCRCC	UTP14A →	+0.232	+0.477	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010826 vs AURKB — BRCA

Explore this scatter interactively →