Bradykinin catabolic process

Across TCGA cell cohorts, RNA activity of the Bradykinin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H2, HLA-B, and CHTOP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H2 grouped by Bradykinin catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	P3H2 →	+2.640	+0.916	<.001	.006	2	6
LUNG_NSCLC_LUAD	HLA-B →	+2.484	+0.926	.004	.008	3	5
KIDNEY	CHTOP →	-0.416	-1.064	.005	.009	3	4
LUNG_SCLC	GABRE →	+3.027	+0.784	<.001	.007	3	4
LARGE_INTESTINE	ZCCHC17 →	-0.574	-0.848	.001	.003	3	4
LARGE_INTESTINE	EFCAB7 →	-0.904	-1.254	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H2 by Bradykinin catabolic process activity — SKIN

Explore this box plot interactively →