Positive regulation of cell-substrate adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, TIMP3, and PDGFB, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-substrate adhesion activity versus LGALS1 in COAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LGALS1 →	+0.719	+0.145	<.001	<.001	3	3
BRCA	TIMP3 →	+1.507	+0.292	<.001	<.001	3	3
COAD	PDGFB →	+0.997	+0.217	<.001	<.001	3	3
BRCA	SEC23A →	+0.720	+0.278	<.001	<.001	3	3
OV	PLTP →	+0.955	+0.178	.006	<.001	3	3
OV	ISM1 →	+1.545	+0.175	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010811 vs LGALS1 — COAD

Explore this scatter interactively →