Positive regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZIC5, HCFC1, and MCM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-substrate adhesion activity versus ZIC5 in SOFT_TISSUE (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZIC5 →	-1.712	-0.232	.004	.003	3	6
BREAST	HCFC1 →	-0.747	-0.205	<.001	.003	3	5
BLOOD_Lymphoma	MCM3 →	-0.814	-0.129	.002	.002	3	5
PANCREAS	TEX10 →	-1.119	-0.319	<.001	<.001	3	5
BLOOD_Lymphoma	CDC25A →	-1.034	-0.140	<.001	.001	3	5
PANCREAS	NOL8 →	-0.906	-0.335	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010811 vs ZIC5 — SOFT_TISSUE

Explore this scatter interactively →